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apalutamide will lessen the extent or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medications which might be CYP2C19 substrates may end up in decreased publicity to these drugs.Diazepam can be a Routine IV controlled substance